Impact of thyroid hormone replacement therapy on the course and functional outcome of aneurysmal subarachnoid hemorrhage. (2024)

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Impact of thyroid hormone replacement therapy on the course and functional outcome of aneurysmal subarachnoid hemorrhage.? ›

Conclusion: SAH patients with THRT show lower burden of ischemia-relevant cerebrovascular events and more favorable outcome. Further experimental and clinical studies are required to confirm our results and elaborate the mechanistic background of the effect of THRT on course and outcome of SAH.

Nimodipine should be given to patients with no neurological deficits after subarachnoid hemorrhage to reduce the risk of new neurological deficits due to vasospasm.

Approximately 35% of patients with a subarachnoid haemorrhage (SAH) die within 3 months, and more than 50% of survivors make an incomplete recovery. Spontaneous subarachnoid haemorrhage.

Traditionally, spasm that develops in large cerebral arteries 3-7 days after aneurysm rupture is considered the most important determinant of brain injury and outcome after aSAH.

Initial care of patients with SAH is directed at identifying the clinical severity and reversing or stabilizing life-threatening conditions, particularly for comatose patients. Important steps include ensuring a secure airway, normalizing cardiovascular function, and treating seizures [1,2].

Recovery. Recovery and prognosis are highly variable and largely dependent on the severity of the initial SAH. In general, one-third of patients who suffer a SAH will survive with good recovery; one-third will survive with a disability or stroke; and one-third will die.

Irregular heartbeats or palpitations

Irregular heartbeats, such as a fast heart rate or heart palpitations, are also possible with this thyroid medication. Sometimes, this can feel like a racing or pounding heart.

Along with an increase in energy levels and a more stable weight, your other symptoms should improve as well. Your sex drive may improve, you may sleep better, pain in your muscles and joints may go away and your mood may improve as a result of treatment for low thyroid or other hormone replacement therapy.

The most common side effects of hormone replacement therapy are: Irregular vagin*l bleeding. Breast tenderness. Mood swings.

Neuropsychiatric disturbances such as depression, personality changes (PC), post-traumatic stress disorder and fatigue are not uncommon, yet are often neglected in patients with SAH [3]. PC is a common phenomenon associated with traumatic head injury, stroke and dementia.

What is the most serious complication of a subarachnoid hemorrhage? ›

Medical complications can also contribute to a change in neurologic status. The significant concerns after an aSAH are rebleeding, hydrocephalus, and vasospasm. The most immediate problem is rebleeding. The most significant risk of rebleeding and mortality is within the first 6 hours of the initial hemorrhage.

Digital subtraction catheter angiography remains the gold standard for diagnosis and characterization of vascular abnormalities, and in many centers, even if the causative lesion is identified on MRA or CTA and it is thought to require surgical management, a catheter study is carried out.

You'll usually be given a medicine called nimodipine to reduce the chances of this happening. This is normally taken for 3 weeks, until the risk of secondary cerebral ischaemia has passed.

If you require emergency treatment because of a ruptured brain aneurysm, you'll initially be given a medication called nimodipine to reduce the risk of the blood supply to the brain becoming severely disrupted (cerebral ischaemia). Either coiling or clipping can then be used to repair the ruptured brain aneurysm.

Most commonly used AEDs for seizure prophylaxis in patients with aSAH include phenytoin and levetiracetam. Phenytoin has been associated with increased risk of DIND, drug-induced fever, and mild cognitive dysfunction at three months [6, 10].